Personal Information

 Assistant Professor

Department of  Biochemistry

Faculty of Sciences

Contact Information

Phone: 6400000 Ext. 64053

Email: mzamzami@kau.edu.sa

Mazin Abdulaziz Zamzami

 Assistant Professor

Profile

Dr Mazin Zamzami is Assistant Professor at the Biochemistry Department in the Faculty of Science at King Abdulaziz University. He was granted his PhD in Clinical Biochemistry from the University of Queensland, Brisbane, Australia in 2012, and he was also granted during the same year a Graduate Certificate of Molecular Biology from UQ.

He joined the KAU family in 2002 as a Lecturer in Biochemistry at the Faculty of Health Sciences. Previously, from around 1997, Dr Zamzami directed the Serology Department as well as worked as a senior laboratory technician in the Clinical Biochemistry Department at Al-Thaguer Hospital, Jeddah, for approximately five years. 

Dr Zamzami has a clinical research interest in the molecular basis of disease, particularly nucleotide metabolic diseases, and pharmacogenetics. He also involved in international collaborative projects with Australia, the USA and UK. Recently he began establishing the first clinical research group for nucleotide metabolic diseases and diagnostics in Saudi Arabia, at the King Abdulaziz University, Jeddah.

He has published articles on non-canonical nucleotides effects and mitochondrial microarrays, as well as presenting at international and national scientific conferences, and he has continued his contribution to research in metabolic diseases.  His research is involved with the Mater Hospital, and collaboration with the University of Queensland, Brisbane, Australia.

Education

  • 1995

    Bachelor degree from Biochemistry Faculty of Science, King Abdulaziz University, جدة, المملكة العربية السعودية

  • 2000

    Master degree from Biochemistry Faculty of Science, King Abdulaziz University, جدة, المملكة العربية السعودية

  • 2012

    Doctorate degree from Chemistry and Molecular Biosciences Faculty of Science, The University of Queensland, برزبن, اســـتراليا

Employment

  • 1997-2002

    Senior Lab Technician , Al-Thaguer Hospital, جدة, المملكة العربية السعودية

  • 2002-2012

    Lecturer, King Abdulaziz University, جدة, المملكة العربية السعودية

  • 2006-2012

    Lecturer, King Abdulaziz University, جدة, المملكة العربية السعودية

Research Interests

Dr Zamzami's research encompasses areas of the molecular basis of disease, particularly nucleotide metabolic diseases and pharmacogenetics, especially related to the medical fields of haematological malignancy and mitochondrial diseases. Dr Zamzami is also involved in a project studying vitamin D deficiency effects in the Saudi population. 

Pharmacogenetics related research is aiming to optimize drug prescribing by minimising serious side effects and improving response, by identifying the genetic differences between individuals affecting drug handling in the body. Dr Zamzami has been particularly interested in the pharmacogenetic effects of the nucleotidase gene ITPA, with nucleotide forming drugs, for example ribavirin (used for treating hepatitis) and thiopurines drugs such as azathioprine and mercaptopurine (used for treating inflammatory diseases and for transplantation and leukemia). 

His work utilises a mix of molecular genetics methods (PCR, RFLP, sequencing  and microarrays),  with analytical chemistry of endogenous and rug metabolites (HPLC and mass spectrometry).

 

Specific projects currently underway:

 

  • The role of non-canonical ‘rogue’ nucleotides and nucleotide drug analogues in disease.
  • Thiopurine metabolism and pharmacogenetics
  • Inherited diseases of nucleotide metabolism (purine and pyrimidine disorders) including gout.
  • The ITPA gene and other 'house-cleaning' genes.

Scientific interests

Courses

Metabolic Regulation and Disorders 315 bioc
Medical biochemistry 416 bioc
Biochemistry of disease 417 bioc
Career skills &technical writing 492 bioc

Areas of expertise